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Announcement of the Call for Applications under the Program:

 

Call No. 02_18_053 for International Mobility of Researchers, Technical and Administrative Staff in Priority Axis 2 of the OP

Project Name: Mobility Support at UP II.

Supported Activity: 1 – Post-docs from abroad in the Czech Rep.

Mobility: 1 – Post-doc from abroad in the Czech Rep. (LF_2)

Hosting Institution/Faculty/Department: Department of Medical biology, Faculty of Medicine and Dentistry

Mobility Location: Palacký University Olomouc, Czech Republic

Duration: 18 months

Term: the job will commence from June 1st,2020

 

Application form

 

Mobility description:

The successful candidate will participate in ongoing projects in the position of Junior research scientist (Post-doc) as a full-time employee (40 hours/week) of the Palacký University with all relevant benefits (lunch subsidy, leave of 40 days/year).

 

Topic: Modulation of molecular signaling and cellular senescence in leukemia progression and therapy

 

Malignant transformation of hematopoiesis is a multistep process, which involves accumulation of somatic mutations and a cascade of multiple cellular events. In addition, germline predisposing variants may interact with somatic events in leukemogenesis. Targeted therapy interfering with abnormal processes in leukemogenesis belongs to the most important challenges in leukemia research. The frame of this project is based on our earlier contributions to the understanding of cooperation between oncogene-induced DNA-damage response (DDR) and inflammatory cytokine network in leukemogenesis. We described DDR as a critical mechanism rate-limiting for malignant transformation by the hematopoietic oncogene, synergizing with inflammatory factors in checkpoint signaling and senescence, thereby counteracting leukemogenesis (Cancer Cell, 2012;21(4):517-31). Recently we elaborated on a concept of protection mechanisms that guard myeloproliferative progenitors from cell-intrinsic and cell-extrinsic DNA damage and thus DDR, facilitating creation of a barrier preventing cell cycle arrest, myelofibrosis and rapid malignant transformation (Oncogene, 2019;38(28):5627-5642). Currently, we test whether and how these processes can be targeted in preventing full leukemia transformation from different preleukemia disease states.

 

The successful candidate will have an opportunity to join a team with long-term expertise in the field and work on a project that encompasses diverse aspects of biochemistry, cellular biology and hematooncology. Using advanced tumor models, including unique mouse strains, we will study anticancer and cytotoxic effects of diverse compounds developed by our collaborators. These progressively-designed small molecule inhibitors or senolytic drugs with potential of therapeutic application will be evaluated on organ, tissue- and cell-level. We will also investigate functional consequences of synthetic lethal interactions in DDR pathway network during the stepwise process

Mobility Support at UP II., CZ.02.2.69/0.0/0.0/18_053/0016919

of leukemia development. Our research group provides platform for international collaborations, substantial stability of funding and intensive interaction with clinical hematooncology.

 

The researcher is obliged to actively participate in a conference / seminar / workshop, etc. organized by the hosting institution at least once in every six months of the mobility.

 

Support for the Researcher’s Family: NO

 

Salary Offered: net salary of 46 500,- CZK

 

Requirements for candidates:

 

Phase I

- The candidate is a post-doc in accordance with the definition; that is, a researcher up to 7 years after being granted the Ph.D. degree or its foreign equivalent1 (equivalent to level 8 of ISCED) as of the date of mobility beginning, and

- Has been active outside the Czech Republic in the field of science and research with the working time of at least 0.5 for at least 2 years (as of the date of mobility beginning) within the last 3 years, or was a Ph.D. student abroad, and

- Proves his/her publication activity (professional publications registered in the databases Web of Science, Scopus or ERIH PLUS, and at the same time publications in the form of “an article”, “book chapters”, “a letter” and “a review”) – at least 2 publication outputs in the last 3 years (as of the date of mobility beginning).

 

The candidates who fail to fulfil the criteria of Phase I set above will be excluded from the selection procedure. The candidates who fulfil the qualification criteria of Phase I proceed to the assessment within Phase II.

 

Phase II - Assessment method:

The fulfilment / non-fulfilment of exclusion criteria within Phase I, as well as the required expertise and requested documentation will be assessed by a committee consisting of at least three members.

The individual candidates will be assessed by the committee at a common meeting according to the following criteria:

 

Criterion 1:

The number and quality of articles in impact factor journals and other publications

Possible rating: min. 0, max. 30 points

 

Criterion 2:

Participation in scientific-research projects (international, national)

Possible rating: min. 0, max. 10 points

 

Criterion 3:

Benefits for the hosting institution within the respective field of study (scientific field) the candidate is applying for

Possible rating: min. 0, max. 10 points

 

The maximum rating achievable is 50 points. When assessing the candidates with regard to criteria 1 and 2, the particular candidate achieves the number of points for fulfilling the particular criterion in accordance with the objectively identifiable value set above. When assessing the candidates with regard to criterion 3 each member of the selection committee awards the points to the particular candidate individually at his/her discretion. The final number of points for the particular candidate is the average of the rating awarded by the individual committee members. The winner of the selection procedure is the candidate who has achieved the most points in the assessment of the individual criteria.

A written record of the assessment procedure will be made, including the information about the composition of the assessment committee, the criteria of candidate assessment, the reasoning of ratings, and the name of the winner.

The results of the assessment procedure will be published on the UP website.

 

Documents requested:

Completed application form with all the requested attachements (form attached)

All documents listed above must be submitted in either Czech or English.

Successful candidates shall not be working at any other university or institution at the time of the expected beginning of their mobility. Any exception has to be requested within the admission procedure.

 

The applications may be submitted in the electronic form to the address Magdalena.svozilova@upol.cz by March 20th,2020.

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